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[PubMed Citation] Summary of clinical and non-clinical studies Hydroxocobalamin, a precursor of vitamin B12, was approved by the Food and Drug Administration (FDA) as an antidote to cyanide poisoning in the United States (Shepherd et al., 2008) and has a history as a treatment of smoke inhalation in France (Fortin, 2010)

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Other BBB transporters such as solute carriers and ATP-binding case families control the transport of other essential molecules, metabolites and nutrients, maintaining the brain homeostasis