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J Leukoc Biol (2008) 83:148492

In the feet, this can lead to: Tingling or pins and needles sensations Numbness or reduced ability to feel pain, heat, or cold Burning or shooting pain, especially at night Muscle weakness or instability when walking Neuropathy often develops gradually, and without early treatment, it can worsen over timeincreasing your risk of injuries, ulcers, and infections

Consider patients whove had prior experiences with such treatments before making decision because its always better not be caught off guard

5,16,17 Patients with low back pain combined with claudicating leg pain that includes bowel and bladder dysfunction, saddle anesthesia, and new or worsening lower extremity weakness should be referred for urgent surgical evaluation