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In almost every cell, glutamine can be used as a substrate for nucleotide synthesis (purines, pyrimidines, and amino sugars), nicotinamide adenine dinucleotide phosphate (NADPH), antioxidants, and many other biosynthetic pathways involved in the maintenance of cellular integrity and function [2,3,4]

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10.1016/j.bbrc.2015.08.049 271

Although there are currently no broadly effective specific treatments for LC, many are under investigation, and certain components have been effective for subsets of LC populations ( 10 , D-ribose for fatigue, anticoagulants and apheresis for abnormal clotting, Sulodexide and Pycnogenol for ED (128)