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Our observed increases in gene expression during initial stages of the plant stress responses may indicate that (i) the translated proteins are susceptible to damage under unfavorable conditions and an increase of transcription is therefore required to maintain the proper thiamine cellular levels

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To confirm that no other DNA damage-responsive PIKK family member phosphorylates CD98HC S103, at least in response to H 2 O 2 , we used inhibitors of DNA-PKcs and ATR (AZD7648 and AZD6738, respectively) and observed no impairment (Fig

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