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[DOI] [PMC free article] [PubMed] [Google Scholar] 35.Stevens SM, Woller SC, Kreuziger LB, et al

Those most at risk include vegans and vegetarians, people with digestive conditions such as Crohn's disease, coeliac disease or IBS, those taking long-term metformin or proton pump inhibitors, older adults whose ability to absorb B12 through the gut declines naturally with age, those with pernicious anaemia, and anyone with a history of chronic alcohol use

Summary: AOD 9604 and retatrutide are both unlicensed investigational compounds in the UK, and there is no clinical evidence or regulatory guidance supporting their combined use

In a study (3) of people with normal levels of the vitamin, a B12 supplement didnt have an effect on depression