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The cells of the AF are specifically derived from a population of Scleraxis ( Scx )+/SRY-related HMG-box ( Sox )9+ progenitors that are originally unorganized but eventually align into the lamellar pattern as determined by actin stress fiber networks (Hayes et al., 1999

In particular, the irregular activation of the HGF/c-MET pathway enhances the survival of glioma cells via PI3K signaling [11], augments the spread of squamous cell carcinoma through STAT3 signaling [12], promotes the attachment of lymphoma cells via PI3K signaling [13], boosts the growth of head and neck squamous cell carcinoma (HNSCC) through MAPK signaling [14], and triggers EMT and invasion in prostate cancer through Erk/MAPK signaling [15]

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