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Over time, this signaling cascade leads to impaired antitumor T cell function, fostering an environment conducive to tumor growth [109]

The activity of mTORC1 is primarily mediated by phosphatidylinositol-3-OH kinase/RAC- serine/threonine-protein kinase/tuberous sclerosis complex (PI3K/AKT/TSC) and liver kinase B1/the mitogen-activated protein kinase (LKB1/AMPK) axis

Current brand names for oral Isotretinoin include Absorica, Amnesteem, Claravis, Myorisan, and Zenatane, which can be obtained only with a prescription from a board-certified dermatologist

Pregnant or breastfeeding women, and individuals with medical conditions or on medication, should consult a healthcare professional before use