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Inhibition of 25-OHC expression or treatment with Fer-1, a ferroptosis inhibitor, significantly suppressed ferroptosis and lipid peroxidation in IMS32 cells and alleviated neurological damage, indicating that 25-OHC may serve as a potential therapeutic target for ALS (Urano et al., 2025)

Such is the case with the combined use of agents that stimulate protein synthesis, such as short-term use of glucocorticoids or omega-3 fatty acids, 52 and agents that prevent catabolism, specifically thalidomide, which downregulates the ubiquitin-proteasome proteolysis pathway involved in protein degradation

The protein similarity somehow reflects the gene arrangement since PtGSTF1 and PtGSTF2 genes are present in tandem on chromosome 2, PtGSTF4 , 5, 6, and 7 genes cluster on the scaffold 36, whereas PtGSTF3 and PtGSTF8 are found at isolated loci on the chromosomes 14 and 17, respectively