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Both reaction rates and protein abundances (inputs) were varied using Latin hypercube sampling (LHS), and partial rank correlation coefficients (PRCCs) 36 were calculated and significant PRCCs reported for pAkt and pERK (outputs) at 120 min that represents steady state (Fig

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MT-I (afamelanotide) is a linear peptide with selective MC1R affinity, while MT-IIs cyclic structure gives it broader receptor binding activity

Biphasic modulation of NOS expression, protein and nitrite products by hydroxocobalamin underlies its protective effect in endotoxemic shock: downstream regulation of COX2, IL1 , TNF , IL6, and HMGB1 expression