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The cofactors FAD and FMN, which include vitamin B2, are transferred to an electron by the enzyme methionine synthase reductase (MTRR) during the subsequent reactivation cycle

( + supplementation activates Sirtuin 2 (SIRT2), enhancing the reciprocal inhibition of forkhead box O1 (FOXO1) and PPAR- to inhibit adipocyte differentiation and induce fat loss