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1 H NMR (500 MHz, Chloroform-d) 7.09 (dd, J=5.9, 3.1 Hz, 1H), 7.03-6.98 (m, 1H), 6.82 (dt, J=8.9, 3.6 Hz, 1H), 6.49 (s, 1H), 4.54-4.48 (m, 1H), 4.48-4.42 (m, 1H), 4.37 (td, J=12.8, 12.3, 6.1 Hz, 2H), 3.97 (ddd, J=26.4, 13.9, 2.4 Hz, 2H), 2.82-2.60 (m, 2H), 2.57 (d, J=5.7 Hz, 2H), 1.98 (q, J=13.1, 9.9 Hz, 2H), 1.57 (s, 2H), 1.51 (dd, J=33.0, 6.6 Hz, 6H), 1.35-1.29 (m, 6H)

Endocytosis of endogenous PrP in polarized ATP7B-KO cells was evaluated with the SAF32 anti-PrP antibody using pulse/chase protocol combined with acid wash as described above

Perimenopause marks a key transitional phase from reproductive maturity to menopause, characterized by the progressive decline in ovarian function and reproductive capacity (1)

These adverse events are usually infusion-rate dependent and resolve with simple supportive measures such as slowing the drip, providing anti-emetics, or alternating cannula sites