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To be clear, the FDA has not yet approved any injectable drugs for skin whitening, and the agency has noted, These products pose a potentially significant safety risk to consumers

The increased intracellular ATP consumption, increased tissue oxygen consumption and oxidative phosphorylation, overexpression of adrenergic receptors, and a decrease in antioxidant defensive mechanisms are the mechanisms of free radicals overproduction that favour OxS in hyperthyroid patients (46)