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SUSTAIN 5: A 30-week, randomized, double-blind, placebo-controlled, parallel-group trial in 397 adult patients with type 2 diabetes evaluating the addition of Ozempic injection 0.5 mg and Ozempic injection 1 mg to basal insulin metformin

Therefore, we decided to employ in vivo microdialysis to ensure the behavior effects observed in rodents were due to a rise in extracellular dopamine level

Because tumor growth also depends on new blood vessels, several reviews describe this as a theoretical concern that has not been resolved in humans (Sehgal et al., Pharmaceuticals, 2025)

Human trials have predominantly used topical or brief systemic dosing, and tolerability is overall reported to be good