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As cardiac IRI is tightly linked to the pro-inflammatory cascades driven by cytokines, neutrophils, and immune signalling, reperfusion-induced release of DAMPs activates pattern recognition receptors, amplifying cytokine production and neutrophil infiltration [27,33]

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At locations, O4 of CHY and ALA109 (position) of 4DES, O6 of CHY and SER117 of 4DES, and O8 of CHY and THR119 position of 4DES, respectively, CHY forms three powerful H-bonds with the 4DES

Hum Exp Toxicol 24(3):129135 Dewidar B et al (2019) TGF- in hepatic stellate cell activation and liver fibrogenesis-updated 2019