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The meta-analysis included 16 studies including patients with asymptomatic hyperuricemia and/or gout treated with febuxostat and were compared with placebo/allopurinol, demonstrating a significant reduction in renal events (doubling of serum creatinine concentration and/or entry into renal replacement therapy): HR 0.56, 95% CI 0.370.84, p = 0.006 and a slight decrease in the fall of glomerular filtration rate (0.90 ml/min/1.73 m2) and in albuminuria.49 Like the observed with allopurinol, there is currently insufficient evidence to suggest treatment with febuxostat for renal or cardiovascular protection in patients with asymptomatic hyperuricemia

doi:10.1039/c0mt00043d [PubMed][Crossref] Krishnamurthy P., Xie T., Schuetz J.D

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Treatment protocol The standard sermorelin treatment protocol entails: Five doses per week Nighttime dosages (to coincide with your bodys natural growth hormone release)22 Regular laboratory testing to track your bodys response (e.g., whether your IGF-1 levels are increasing) While the onset of effects may vary depending on various factors age, body mass, desired health outcomes sermorelin treatment generally follows a three-part timeline: Initiation: In the first 1-4 weeks, your physician monitors your tolerance and response to the medication