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It is suggested that 24 S ,25epoxycholesterol acts as a ligand for the liver X receptor, which exists as a heterodimer with the retinoic X receptor to inhibit the transcription of genes for cholesterol biosynthesis as well as directly inhibiting or accelerating the degradation of such enzymes in the process as HMG-CoA reductase and squalene synthase

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In this context, we present a glutathione-activated NIR-II probe, LJ-GSH, designed for metastatic tumor imaging and specific imaging-guided tumor resection