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Strikingly, ABCB1 expression in distal, median, and proximal segments of the small intestine was significantly correlated with TAC area-under-the-curve (AUC) values, paralleling shifts in microbial taxa (e.g., high abundance of Akkermansia and Alistipes and low abundance of Oscillibacter and Ruminococcus) under the administration of TAC ( in vivo models