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PloS one 10, e0134142

Oxidative stress and free radical accumulation may lead to sustained immunocyte challenge and result in depletion of intracellular glutathione

These changes happen in with CDR: Vitamin D activation reduced Glutathione production reduced Methylation pathway dysfunction Increased histamine and mast cell activation Dysregulation of the heme pathway Decrease of serotonin and melatonin production Reductions in heavy metal clearance Disruptions to the GI tract Cell wall hardens One of the major problems happening in healthcare is addressing these upstream issues and not addressing the ROOT Factors