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Treatments containing ingredients like vitamin C, licorice root, and kojic acid help reduce hyperpigmentation by inhibiting tyrosinase, an enzyme responsible for the formation of skin-darkening melanin," says Ni'Kita Wilson, a cosmetic chemist in New York City

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5-Rs isoforms (types 1, 2 and 3) are widely distributed in many tissues including the central nervous system, and inhibition of these enzymes results in blockade of synthesis of several key hormones and neuro-active steroids ( Figure ) leading to a host of adverse effects, including loss of or reduced libido, erectile dysfunction, orgasmic dysfunction, increased high Gleason grade prostate cancer (PCa), observed heart failure and cardiovascular events in clinical trials, and depression

The chemotherapy induction was based in all cases on the combination of cyclophosphamide (100%), 5-fluorouracil (100%) with adriamycin (36%) or epirubicin (51%) or methotrexate (13%)