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Another study of nine MS patients reveals some correlation with microbiome composition changes and an inflammatory cytokine shift in the blood during the weeks of treatment via probiotics (Tankou et al., 2018a)

Although THC possesses neuroprotective antioxidant properties through non-CB1R pathways [33], it also upregulates plasma inflammatory cytokines [34], increases vulnerability to ischemic stroke in young people [35], increases mitochondrial dysfunction [36, 37] and alters gene pathways associated with mitochondrial oxidative phosphorylation [38]

Other types of cancer or immortalized cell lines have been used as models of mitochondrial diseases (Wilkins et al., 2014)