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For a deeper dive into these mechanisms, explore our guide: Can Curcumin Support Brain Fog and Inflammation in Long COVID and ME/CFS

Left panel (Mechanism of Action & Pharmacodynamics) : Imipramine inhibits the serotonin transporter (SERT) and norepinephrine transporter (NET), resulting in increased synaptic concentrations of serotonin and norepinephrine (dual monoamine reuptake inhibition)

Thus, to answer this question, we conducted analyses using only heparinized plasma (Preparation Condition 1) and EDTA-treated plasma (Preparation Condition 2) which were both deproteinized prior to storage at 80 o C

However, the efficacy of these interventions varies due to individual genetic backgrounds, dietary habits, and baseline microbiome differences [251, 259,260,261,262]