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Introduction Erastin (which derives its name from being an eradicator of RAS and ST-expressing cells) is a small molecule that was first reported as inducing synthetic lethality in cancer cells expressing an RAS oncogene [1] through an oxidative stress mechanism under strong RAS-RAF-MEK signaling [2]

The TIF-1, and especially the TIF1, seem to be cancer-specific with 89% specificity for cancer-associated dermatomyositis (53