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Turnock DL, Gibbs DN

Recognizing the musculoskeletal manifestations of vitamin D deficiency

The alanine at position 2 of the peptide was substituted with Aminoisobuturic acid (Aib) to protect the molecule from DDP-IV inactivation, and a lactam bridge was introduced between amino acids 16 and 20 to stabilize the secondary structure to ensure glucagon receptor potency