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This enzymatic system was first discovered in 1913 [39] and constitutes two cytosolic enzymes, glyoxalase-I (Glo-I, EC 4.4.1.5) and glyoxalase-II (Glo-II, EC 3.1.2.6.)

Its important to note that the negative effects of being overweight on cognitive performance seem to begin before reaching very old age, as indicated by the findings related to mean-level cognitive performance and only one ability showing differences in performance changes over time

10.1016/j.devcel.2024.03.018 Dev Cell