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Synthetic fresh urine (SU 1 -SU 4 ) that mimicked the composition of real fresh urine was prepared by dissolving urea and inorganic compounds (NaCl, Na 2 SO 4 , KCl, MgCl 2 .6H 2 O, NaH 2 PO 4 , CaCl 2 , and NH 4 Cl) in Milli-Q water and adjusting the pH of the solution with NaOH (Table 1)

Inflammatory chemicals flood the damaged tissue, triggering pain receptors

This suggests inherent stability in acidic environments that many other peptides lack, according to preclinical findings

Similarly, impeding the CYFIP1/Rac1 interaction or the CYFIP1/NCKAP1 dimer formation, could have a dual beneficial effect in concomitantly restoring normal levels of protein synthesis and actin dynamics, both processes being dysregulated in FXS