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Prolonged ischemia leads to necrosis in cardiomyocytes, which is irreversible myocardial damage

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We note that CPT codes 55712, 55713, 55714, and 55715 were listed as placeholder codes 5XX07, 5XX08, 5XX09, and 5XX10 respectively, in OPPS Addendum B and Addendum O that were released with the CY 2026 OPPS/ASC proposed rule

Addressing instability, PK variability, biomarker gaps, and ecological uncertainty through standardized, biomarker-driven, and context-specific approaches will be essential to bridge the gap between experimental promise and responsible pharmacological application