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After being informed that a cure was unlikely, the owner consented to palliative chemotherapy, aiming for symptom relief and additional time with acceptable side effects

Jiang C, Wang X, Li X, Inlora J, Wang T, Liu Q, et al

Interferon- (IFN-) predominantly acts through the JAK1/2-STAT1 pathway to induce M1 polarization, enhancing the expression of other proinflammatory factors such as IL-6 and tumor necrosis factor- (TNF-), with TNF- being a potent promoter of M1 polarization as well as a significant inhibitor of M2 polarization [47]