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Stress adaptation in a pathogenic fungus

While skeletal muscle is the primary producer and storage facility of l-glutamine, the gastrointestinal tract is by far its greatest and most demanding consumer

Activation of ATM by oxidative stress or genotoxic damage was recently reported to activate AMPK and the tuberous sclerosis complex 2 (TSC2), which in turn participates in energy sensing and growth factor signaling to repress the kinase mTOR in the mTORC1 complex [83]

Enclomiphene represents the first step in a tiered approach that preserves optionality, specifically the option of fertility and the option of restoring endogenous function if the pharmacological support is discontinued