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When appropriately induced, trained immunity is protective against infection and tumors, and reinforces tissue repair upon acute damage 14,16,17,18,19,20,21 , but its maladaptation leads to chronic inflammatory pathologies and hinders tissue repair after repetitive damage 11,19,22,23,24,25,26,27,28,29

Unexpectedly, anti-PDGFR alone treatment augmented tumor angiogenesis in FGF-2 + tumors

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Alterations as small as15 mV in the redox potential can result in transcription factor translocation and activation or deactivation, depending on the direction of the redox shift [36], [37], [38]