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Description

J Glob Infect Dis 3(2):199-201, 2011

Apart from the ETM1 locus, ETM2 (OMIM: 602134) [ 69 ] and ETM3 (OMIM: 611456) [ 70 ] have also been considered as causal genetic factors for ET in a genome wide linkage scan, without though, as in case of ETM1 locus, the genes and the causal mutations for both, ETM2 and ETM3, loci being identified [ 3 ]

Subsequently, early-phase clinical trials incorporating validated biomarkers and adaptive designs should be initiated to evaluate their therapeutic value in OSCC patients