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In the past couple decades, investigations into PD pathology have revealed some distinct features, such as iron accumulation, lipid peroxidation, glutathione depletion, CoQ10 deficiency, glutathione peroxidase (Gpx4) reduction, mitochondrial lesions, among others 7

PDAC cells tend to decompose and utilize extracellular proteins for amino acids, while NSCLC cells extract nitrogen by breaking down circulating BCAAs

However, the potential effects of the Set7/9-mediated methylation of FOXO3 on its target antioxidant genes, MnSOD and CAT, were not investigated in this study

ZIMMERING, S., MASON, J.M., VALENCIA, R., & WOODRUFF, R