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Once reaching the liver, these macrophages are inhibited by sUA, which further prevents the nuclear translocation of GLUT-4 and impedes insulin receptor substrate 2 (IRS2)/Phosphoinositide 3-kinase (PI3K)/AKT signaling

Veys KR, DHauwers KW, van Dongen A, Janssen MC, Besouw MTP, Goossens E, van den Heuvel LP, Wetzels A, Levtchenko EN (2018) First successful conception induced by a male cystinosis patient