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Specifically, GSH concentrations are increased by upregulation of the GCS enzyme through the nuclear erythroid factor 2-related factor 2 (NRF2) pathway and GSH concentrations are decreased by the -glutamyltranspeptidase (GGT) enzyme present on the external surface of certain cell types [71,77,78,96,[109], [110], [111]] (Table 1 and Fig

g i , c-Fos or c-Jun was stably knocked down in HCT116 cells, followed by transfection with WT or G12D mutant KRAS plasmids

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