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For example, elevated ROS were shown to inhibit EGFR and lectin receptor endocytosis in fibroblasts, likely by preventing their ubiquitination [90]

10.1016/j.synbio.2019.10.003

Hypoxia has been shown to promote the self-renewal capacity of GSCs as well as the ability to promote a more stem-like phenotype in the non-stem cell population by the up-regulation of important stem cell factors including Oct4 or Nanog (Heddleston et al., HIF-2 is likewise expressed in GSCs at oxygen levels comparable to normal in vivo levels (25%)