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In the amygdala, an upregulation of orexin expression has been associated with depression, while exercise-induced suppression of orexin in this region exerts antidepressant effects [136, 137]

Oxidative stress markers in bipolar disorder: a meta-analysis

The expression of ORF3a in human embryonic kidney 293 T-antigen cells (HEK293T) cells increased the stability of HIF-1 and induced mROS production, which is an activator of HIF-1