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This pain can be sudden and severe, often triggered by routine activities such as chewing, speaking, or even touching your face

For instance, the development of autoimmune diseases is stimulated by iodine (excess or deficiency), smoking, stress, and chemical contaminants (like polyaromatic hydrocarbons), medicine (like amiodarone and interferon-alpha (IFN), and bacterial and viral infections (like hepatitis C virus and Yersinia enterocolitica)

Preclinical models show activity over 48 weeks

Extremes matter: patients under 50 kg often do well at the lower end, patients over 100 kg may sit at the upper end of standard ranges