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Concomitantly, the activity levels of antioxidant enzymes GSH, GST and GPx were significantly higher in the liver of SR4-treated mice compared with the control (Fig

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Drug delivery to the brain To overcome the BBB, various approaches have been developed for the delivery of a therapeutic to the brain

Increased oxidative stress further accelerated aging by raising serum TNF- levels, reducing Sirtuin 6 (Sirt6) expression in long bones, and promoting NF-B acetylation and cathepsin K overexpression and activation