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If the heart is not able to pump blood as normal it will try to make up for the poor circulation by increasing the amount of blood it is circulating through the body

STOP 101: a phase 1, randomized, open-label, comparative bioavailability study of INP104, dihydroergotamine mesylate (DHE) administered intranasally by a I123 precision olfactory delivery (POD() ) device, in healthy adult subjects