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When detoxification capacity is overwhelmed: Oxidative stress rises Mitochondrial efficiency declines Cellular recovery slows Pain sensitivity increases This creates a compounding effect: impaired detoxification further strains nutrient reserves, and diminished nutrient reserves reduce detox efficiency

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Landscapes Health & Medical Sciences (AREA) Chemical & Material Sciences (AREA) Medicinal Chemistry (AREA) Pharmacology & Pharmacy (AREA) Epidemiology (AREA) Life Sciences & Earth Sciences (AREA) Animal Behavior & Ethology (AREA) General Health & Medical Sciences (AREA) Public Health (AREA) Veterinary Medicine (AREA) Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA) Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA) Abstract Novel brain targeted low molecular weight, hydrophobic antioxidants and use of antioxidants in treatment of central nervous system neurodegenerative disorders such as Parkinson's, Alzheimer's and Creutzfeldt-Jakob's diseases and in treatment of conditions of peripheral tissues, such as acute respiratory distress syndrome, amyotrophic lateral sclerosis, atheroscierotic cardiovascular disease and multiple organ dysfunction, in which oxidants are overproduced

Front Endocrinol 13:920340 Lee HY, Ithnin A, Azma RZ, Othman A, Salvador A, Cheah FC (2022) Glucose-6-phosphate dehydrogenase deficiency and neonatal hyperbilirubinemia: insights on pathophysiology, diagnosis, and gene variants in disease heterogeneity