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As a transporter for the reverse transport of glutamine and cysteine, system Xc-is influenced by the concentration of glutamate, which further affects cellular cysteine intake ( 4.1.2 Inhibiting GSH/GPX4 axis inducing ferroptosis There is a category of drugs that induce ferroptosis by inhibiting the GSH/GPX4 axis, including RAS-Selective Lethal 3 (RSL3), statins, Ferroptosis Inducing 56 (FIN56), FINO2, ML 162, ML 210, and Withaferin

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Third, although protective effects were observed in preclinical models, their applicability to human OA remains uncertain, and well-designed clinical trials are necessary to validate these findings