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doi: 10.1016/j.bbrc.2021.03.055 112 DixonSJLembergKMLamprechtMRSkoutaRZaitsevEMGleasonCEet al

Compared to healthy controls, MS patients show significantly downregulated expression of TET2 in peripheral blood mononuclear cells (PBMCs), correlating with abnormal methylation patterns in the promoter regions of TET2 and DNMT1 (134)

Since RidAs chaperone function is not dependent on ATP, RidA, similar to Hsp33, is perfectly suited to function under HOCl-stress conditions, which transiently incapacitate ATP-dependent chaperone systems

Across the SURPASS phase 3 programme versus placebo and active comparators, including semaglutide, tirzepatide has shown superior dose-dependent reductions in HbA1c levels up to 2.5% and body weight up to 13%, compared with all comparators [88-91]