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In addition, deleting a-synuclein or ACSL4 in LUHMES cells, neuronal precursor cells, resulted in a robust reduction in ePE and ePC levels regardless of fatty acid chain species 138

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Ferroptotic tubular cells release DAMPs (e.g., HMGB1) and lipid peroxidation products (e.g., 4-HNE), which activate pattern recognition receptors on macrophages and neutrophils, inducing the secretion of pro-inflammatory cytokines (e.g., IL-33 and MCP-1)