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Their study showed decreased production of methyltransferase Ezh2 in the atria of aged mice with AF [Figure 6] and unveiled that Ezh2 restored H3K27me3 levels in the promoter regions of CDKN2a and Timp4 genes in primary mouse atrial fibroblasts at late passages, preventing senescence development and alleviating profibrotic effects [156]

The permutation test was estimated by randomizing the Y-matrix (class assignment or continuous variables) while the X-matrix (peak intensity in NMR spectra) was fixed

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Research has established its roles in stimulating collagen and elastin synthesis, promoting wound healing and tissue remodelling, exhibiting antioxidant activity, and modulating broad patterns of gene expression