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Rats were housed under with ad libitum source of food and water throughout the experiment

In the abstract, the concluded that: "A lack of an increase in corin expression or activation can be postulated to be a possible important pathophysiological mechanism responsible for the natriuretic peptide paradox in dogs with CHF, and warrants further investigation." One possible uniquely valuable use for natriuretic peptides tests is if the dog is approaching heart failure (HF) without any symptoms

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Malfatti CR, Royes LF, Francescato L, Sanabria ER, Rubin MA, Cavalheiro EA, Mello CF (2003) Intrastriatal methylmalonic acid administration induces convulsions and TBARS production, and alters Na+, K+ -ATPase activity in the rat striatum and cerebral cortex