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Loss of dopaminergic neurons involves neuroinflammatory mechanism and oxidative stress through the elevated level of inducible nitric oxide synthase (iNOS) followed by activated astrogliosis, T-cell infiltration, and microglia that leads to the accumulation of NO and O 2 free radicals

LIFT-AD Phase 2/3 Failure The larger LIFT-AD trial fails both primary and key secondary endpoints, raising questions about the clinical viability of fosgonimeton

It enhances the activity of immune cells, including natural killer (NK) cells and white blood cells, which are critical for robust immune responses

And many of these compounds are hard to patent