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Drechsler S, Osuchowski M

This is due to the fact that obesity enhances the production of ROS in mitochondrial, which can damage the lipid membranes, proteins, and enzymes of the respiratory chain in the mitochondria, as well as DNA (77)

While in vitro studies suggest glucosamine provides structural precursors, clinical osteoarthritis reviews note that literature to date has not proven glucosamine sulfate supplements to slow disease progression or effectively decrease osteoarthritis-associated pain, with randomized control studies showing conflicting results

Funding The author declares that no funds, grants, or other support were received during the preparation of this manuscript