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Sixteen novel mutations in the Cu/Zn superoxide dismutase gene in amyotrophic lateral sclerosis: a decade of discoveries, defects and disputes

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Loss of dopaminergic neurons involves neuroinflammatory mechanism and oxidative stress through the elevated level of inducible nitric oxide synthase (iNOS) followed by activated astrogliosis, T-cell infiltration, and microglia that leads to the accumulation of NO and O 2 free radicals