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The recent approach of regenerative medicine using mesenchymal stem cells (MSCs) could be advantageous for the treatment of ACLF as these cells can downregulate inflammatory response by inducing antiinflammatory events and prevent hepatic damage and fibrosis by inhibiting hepatic stellate cell activation and collagen synthesis

By improving mitochondrial membrane potential and ATP synthesis, MI protects granulosa and cumulus cells from oxidative injury, thereby preserving oocyte competence (152)

Another major barrier is the development of resistance mechanisms in patients, which are not always predictable from preclinical data (150)

Sevilla, M