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Int J Androl (2006) 29(1):1407

1A Schematic illustration of pathways regulated by NNMT, including the NAD+ biosynthesis salvage pathway starting from NA as a precursor that feeds into energy metabolism, methionine cycle that regulates intracellular SAM concentrations and thus cellular epigenetic modifications and polyamine flux, and clearance of NA by conversion to 1-MNA and excretory products

Glutathione is generally well tolerated, but some individuals may experience mild side effects such as gastrointestinal discomfort

A human study suggests oral glutathione is poorly absorbed, with negligible plasma concentrations found after administration of a single 3 g oral dose