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All animals were housed under specific pathogen-free conditions at the TIGEM animal facility (Pozzuoli, Italy) with 12-h light/dark cycles and received food and water ad libitum with Cu in diet at 8 g/kg concentration (Cat, #FRDBA 10-10

We elaborate on metabolic changes for macrophages, neutrophils, vascular endothelial cells, vascular smooth muscle cells and lymphocytes in the context of atherosclerosis and its co-morbidities hypertension, dyslipidemia, and diabetes